920509

3-(7-(tert-Butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)propanoic acid

Manufacturer: Sigma Aldrich

Synonym(S): Rigid linker for PROTAC® development

Select a Size

Pack Size SKU Availability Price
50 MG 920509-50-MG In Stock ₹ 44,788.50

920509 - 50 MG

₹ 44,788.50

In Stock

Quantity

1

Base Price: ₹ 44,788.50

GST (18%): ₹ 8,061.93

Total Price: ₹ 52,850.43

form

powder

Quality Level

100

reaction suitability

reagent type: linker

functional group

Boccarboxylic acid

storage temp.

2-8°C

SMILES string

CC(C)(OC(N1CCN2C(CCC(O)=O)=CN=C2C1)=O)C

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Description

  • Application: 3-(7-(tert-Butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)propanoic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.Similar linkers in this series:920568920657ENAH38A2CCD6AC5372910424
  • Other Notes: Portal: Building PROTAC® Degraders for Targeted Protein DegradationCrosslinkers for BioconjugationTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
  • Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Compare Similar Items

Show Difference

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Sigma Aldrich

920509

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form:
powder

Quality Level:
100

reaction suitability:
reagent type: linker

functional group:
Boccarboxylic acid

storage temp.:
2-8°C

SMILES string:
CC(C)(OC(N1CCN2C(CCC(O)=O)=CN=C2C1)=O)C

Img

Ricca Chemical Company

920516

--


form:
__

Quality Level:
__

reaction suitability:
__

functional group:
__

storage temp.:
__

SMILES string:
__

Img

Supelco

92052

≥98.0% (GC)...


form:
liquid

Quality Level:
100

reaction suitability:
__

functional group:
__

storage temp.:
__

SMILES string:
[H][C@@]1([C@@]2([H])CN3CCCC[C@@]3([H])[C@@](C2)([H])C4)N4CCCC1

Img

Sigma Aldrich

920533

--


form:
powder or crystals

Quality Level:
100

reaction suitability:
reagent type: linker

functional group:
Boccarboxylic acid

storage temp.:
2-8°C

SMILES string:
CC(C)(OC(N1CCC(CC1)CC2=NC=CN2CC(O)=O)=O)C