920606

(S,R,S)-AHPC-piperazine-pyridine-alkyne-NH2 hydrochloride

Manufacturer: Sigma Aldrich

Synonym(S): (2S,4R)-1-((S)-2-(4-(4-(5-(3-Aminoprop-1-yn-1-yl)pyridin-2-yl)piperazin-1-yl)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, Crosslinker−E3 Ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader, VH032 conjugate

Select a Size

Pack Size SKU Availability Price
50 MG 920606-50-MG In Stock ₹ 61,085.48

920606 - 50 MG

₹ 61,085.48

In Stock

Quantity

1

Base Price: ₹ 61,085.48

GST (18%): ₹ 10,995.386

Total Price: ₹ 72,080.866

ligand

VH032

Quality Level

100

form

powder or crystals

reaction suitability

reactivity: carboxyl reactivereagent type: ligand-linker conjugate

functional group

amine

storage temp.

2-8°C

SMILES string

CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCN(CC4)CCN4C5=CC=C(C#CCN)C=N5)=O)C(C)(C)C)=O)=O)C=C2.Cl

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Description

  • Application: Protein degrader building block (S,R,S)-AHPC-piperazine-pyridine-alkyne-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a rigid linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
  • Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC® Degraders for Targeted Protein DegradationTargeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug DiscoveryImpact of linker length on the activity of PROTACs
  • Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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ligand:
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Quality Level:
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form:
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reaction suitability:
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amine

storage temp.:
2-8°C

SMILES string:
CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCN(CC4)CCN4C5=CC=C(C#CCN)C=N5)=O)C(C)(C)C)=O)=O)C=C2.Cl

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CC(C)(OC(N1CC2(CCCCN(C2=O)C3=CC=C(C(O)=O)C=C3)C1)=O)C

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reaction suitability:
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CC(C)(OC(N1CC2(CCCCN(C2=O)C3=CC=NC(C(O)=O)=C3)C1)=O)C

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SMILES string:
CC(C)(OC(N1CC2(CCCCN(C2=O)C3=CC=C(C(O)=O)N=C3)C1)=O)C