(S,R,S)-AHPC-piperazine-pyridine-alkyne-NH2 hydrochloride
Manufacturer: Sigma Aldrich
Synonym(S): (2S,4R)-1-((S)-2-(4-(4-(5-(3-Aminoprop-1-yn-1-yl)pyridin-2-yl)piperazin-1-yl)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, Crosslinker−E3 Ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader, VH032 conjugate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 920606-50-MG | In Stock | ₹ 61,085.48 |
920606 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 61,085.48
GST (18%): ₹ 10,995.386
Total Price: ₹ 72,080.866
ligand
VH032
Quality Level
100
form
powder or crystals
reaction suitability
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group
amine
storage temp.
2-8°C
SMILES string
CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCN(CC4)CCN4C5=CC=C(C#CCN)C=N5)=O)C(C)(C)C)=O)=O)C=C2.Cl
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Description
- Application: Protein degrader building block (S,R,S)-AHPC-piperazine-pyridine-alkyne-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a rigid linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
- Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC® Degraders for Targeted Protein DegradationTargeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug DiscoveryImpact of linker length on the activity of PROTACs
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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ligand: VH032
Quality Level: 100
form: powder or crystals
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
SMILES string: CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCN(CC4)CCN4C5=CC=C(C#CCN)C=N5)=O)C(C)(C)C)=O)=O)C=C2.Cl
ligand: __
Quality Level: 100
form: powder
reaction suitability: reagent type: linker
functional group: Boccarboxylic acid
storage temp.: 2-8°C
SMILES string: CC(C)(OC(N1CC2(CCCCN(C2=O)C3=CC=C(C(O)=O)C=C3)C1)=O)C
ligand: __
Quality Level: 100
form: powder
reaction suitability: reagent type: linker
functional group: Boccarboxylic acid
storage temp.: 2-8°C
SMILES string: CC(C)(OC(N1CC2(CCCCN(C2=O)C3=CC=NC(C(O)=O)=C3)C1)=O)C
