920614
4-(2-(tert-Butoxycarbonyl)-5-oxo-2,6-diazaspiro[3.6]decan-6-yl)benzoic acid
Manufacturer: Sigma Aldrich
Synonym(S): Rigid linker for PROTAC® development
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 920614-50-MG | In Stock | ₹ 66,162.40 |
920614 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 66,162.40
GST (18%): ₹ 11,909.232
Total Price: ₹ 78,071.632
form
powder
Quality Level
100
reaction suitability
reagent type: linker
functional group
Boccarboxylic acid
storage temp.
2-8°C
SMILES string
CC(C)(OC(N1CC2(CCCCN(C2=O)C3=CC=C(C(O)=O)C=C3)C1)=O)C
Related Products
Description
- Application: 4-(2-(tert-Butoxycarbonyl)-5-oxo-2,6-diazaspiro[3.6]decan-6-yl)benzoic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.Similar linkers in this series:920592920711920622920630
- Other Notes: Portal: Building PROTAC® Degraders for Targeted Protein DegradationCrosslinkers for BioconjugationTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
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form: powder
Quality Level: 100
reaction suitability: reagent type: linker
functional group: Boccarboxylic acid
storage temp.: 2-8°C
SMILES string: CC(C)(OC(N1CC2(CCCCN(C2=O)C3=CC=C(C(O)=O)C=C3)C1)=O)C
form:
powder
Quality Level:
100
reaction suitability:
reagent type: linker
functional group:
Boccarboxylic acid
storage temp.:
2-8°C
SMILES string:
CC(C)(OC(N1CC2(CCCCN(C2=O)C3=CC=C(C(O)=O)C=C3)C1)=O)C
form: powder
Quality Level: 100
reaction suitability: reagent type: linker
functional group: Boccarboxylic acid
storage temp.: 2-8°C
SMILES string: CC(C)(OC(N1CC2(CCCCN(C2=O)C3=CC=NC(C(O)=O)=C3)C1)=O)C
form:
powder
Quality Level:
100
reaction suitability:
reagent type: linker
functional group:
Boccarboxylic acid
storage temp.:
2-8°C
SMILES string:
CC(C)(OC(N1CC2(CCCCN(C2=O)C3=CC=NC(C(O)=O)=C3)C1)=O)C
form: powder
Quality Level: 100
reaction suitability: reagent type: linker
functional group: Boccarboxylic acid
storage temp.: 2-8°C
SMILES string: CC(C)(OC(N1CC2(CCCCN(C2=O)C3=CC=C(C(O)=O)N=C3)C1)=O)C
form:
powder
Quality Level:
100
reaction suitability:
reagent type: linker
functional group:
Boccarboxylic acid
storage temp.:
2-8°C
SMILES string:
CC(C)(OC(N1CC2(CCCCN(C2=O)C3=CC=C(C(O)=O)N=C3)C1)=O)C
form: powder
Quality Level: 100
reaction suitability: reagent type: linker
functional group: Boccarboxylic acid
storage temp.: 2-8°C
SMILES string: CC(C)(OC(N1CCCC(C1)CN2C=CC(C(O)=O)=N2)=O)C
form:
powder
Quality Level:
100
reaction suitability:
reagent type: linker
functional group:
Boccarboxylic acid
storage temp.:
2-8°C
SMILES string:
CC(C)(OC(N1CCCC(C1)CN2C=CC(C(O)=O)=N2)=O)C