921319
Pomalidomide-methylamino-PEG1-NH2 hydrochloride
Manufacturer: Sigma Aldrich
Synonym(S): 3-((2-(2-Aminoethoxy)ethyl)(methyl)amino)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propanamide hydrochloride, Crosslinker–E3 Ligase l, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrade
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 921319-50-MG | In Stock | ₹ 64,549.48 |
921319 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 64,549.48
GST (18%): ₹ 11,618.906
Total Price: ₹ 76,168.386
ligand
pomalidomide
Quality Level
100
form
(Powder or Crystals or Solid or Chunks)
reaction suitability
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group
amine
storage temp.
2-8°C
SMILES string
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCN(C)CCOCCN)=O)=O)NC1=O.Cl
Related Products
Description
- Application: Protein degrader builiding block Pomalidomide-methylamino-PEG1-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Automate your CRBN-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)
- Other Notes: Technology Spotlight:Degrader Building Blocks for Targeted Protein DegradationPortal:Building PROTAC® Degraders for Targeted Protein Degradation Targeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug DiscoveryImpact of linker length on the activity of PROTACs
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
Pictograms
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 2
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
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ligand: pomalidomide
Quality Level: 100
form: (Powder or Crystals or Solid or Chunks)
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
SMILES string: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCN(C)CCOCCN)=O)=O)NC1=O.Cl
ligand:
pomalidomide
Quality Level:
100
form:
(Powder or Crystals or Solid or Chunks)
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
SMILES string:
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCN(C)CCOCCN)=O)=O)NC1=O.Cl
ligand: C5 Lenalidomide
Quality Level: 100
form: powder or crystals
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
SMILES string: O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(COCCOCCOCCOCCOCCOCCCCCCN)=O)=CC=C31.Cl
ligand:
C5 Lenalidomide
Quality Level:
100
form:
powder or crystals
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
SMILES string:
O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(COCCOCCOCCOCCOCCOCCCCCCN)=O)=CC=C31.Cl
ligand: __
Quality Level: 200
form: powder
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200
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reaction suitability:
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ligand: __
Quality Level: 200
form: powder
reaction suitability: __
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SMILES string: __
ligand:
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Quality Level:
200
form:
powder
reaction suitability:
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functional group:
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storage temp.:
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SMILES string:
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