922153
(S,R,S)-VL285 Phenol-C3-piperazine hydrochloride
Manufacturer: Sigma Aldrich
Synonym(S): (2S,4R)-4-Hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)-N-(4-(4-methylthiazol-5-yl)-2-((6-(3-(piperazin-1-yl)propoxy)pyridin-3-yl)methoxy)benzyl)pyrrolidine-2-carboxamide, Crosslinker−E3 Ligase ligand conjugate, VHL protein degrader building block for PROTAC® research
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 922153-50-MG | In Stock | ₹ 44,270.00 |
922153 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 44,270.00
GST (18%): ₹ 7,968.60
Total Price: ₹ 52,238.60
ligand
VL285 phenol
Quality Level
100
form
solid
reaction suitability
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group
amine
storage temp.
2-8°C
SMILES string
O=C([C@@H]1C[C@@H](O)CN1C([C@H](C(C)C)N2CC(C=CC=C3)=C3C2=O)=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4OCC6=CC=C(OCCCN7CCNCC7)C=N6.Cl
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Description
- Application: Protein degrader building block (S,R,S)-VL285 Phenol-C3-piperazine hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand with alternative exit vector from the widely used VH032 (901490), a linker with added rigidity, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
- Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC® Degraders for Targeted Protein DegradationTargeted Protein Degradation by Small MoleculesTargeted Protein Degradation: from Chemical Biology to Drug DiscoveryHaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion ProteinsDifferential PROTAC substrate specificity dictated by orientation of recruited E3 ligase
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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ligand: VL285 phenol
Quality Level: 100
form: solid
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
SMILES string: O=C([C@@H]1C[C@@H](O)CN1C([C@H](C(C)C)N2CC(C=CC=C3)=C3C2=O)=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4OCC6=CC=C(OCCCN7CCNCC7)C=N6.Cl
ligand:
VL285 phenol
Quality Level:
100
form:
solid
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
SMILES string:
O=C([C@@H]1C[C@@H](O)CN1C([C@H](C(C)C)N2CC(C=CC=C3)=C3C2=O)=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4OCC6=CC=C(OCCCN7CCNCC7)C=N6.Cl
ligand: VL285 phenol
Quality Level: 100
form: solid
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
SMILES string: O=C([C@@H]1C[C@@H](O)CN1C([C@H](C(C)C)N2CC(C=CC=C3)=C3C2=O)=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4OCCN(C)CCOCCN.Cl
ligand:
VL285 phenol
Quality Level:
100
form:
solid
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
SMILES string:
O=C([C@@H]1C[C@@H](O)CN1C([C@H](C(C)C)N2CC(C=CC=C3)=C3C2=O)=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4OCCN(C)CCOCCN.Cl
ligand: __
Quality Level: 100
form: powder or chunks
reaction suitability: __
functional group: __
storage temp.: 2-8°C
SMILES string: __
ligand:
__
Quality Level:
100
form:
powder or chunks
reaction suitability:
__
functional group:
__
storage temp.:
2-8°C
SMILES string:
__
ligand: __
Quality Level: 100
form: liquid
reaction suitability: __
functional group: __
storage temp.: __
SMILES string: CC(=O)c1c(C)cc(C)cc1C
ligand:
__
Quality Level:
100
form:
liquid
reaction suitability:
__
functional group:
__
storage temp.:
__
SMILES string:
CC(=O)c1c(C)cc(C)cc1C