925004
E7820-PEG1-NH2 hydrochloride
Manufacturer: Sigma Aldrich
Synonym(S): N-(2-(2-Aminoethoxy)ethyl)-3-(N-(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl)benzamide, Crosslinker−E3 Ligase ligand conjugate hydrochloride, DCAF15 protein degrader building block
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 925004-50-MG | In Stock | ₹ 39,060.00 |
925004 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 39,060.00
GST (18%): ₹ 7,030.80
Total Price: ₹ 46,090.80
ligand
E7820
Quality Level
100
reaction suitability
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group
amine
storage temp.
2-8°C
Related Products
Description
- Application: Protein degrader building block E7820-PEG1-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. This conjugate contains a DCAF15-recruiting ligand E7820 (SML2950), a PEG linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. Protein Degrader Building BlocksTechnology Spotlight: DCAF15 Degrader Building Blocks for Targeted Protein Degradation
- Other Notes: In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones
- Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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ligand: E7820
Quality Level: 100
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
ligand:
E7820
Quality Level:
100
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
ligand: E7820
Quality Level: 100
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
ligand:
E7820
Quality Level:
100
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
ligand: E7820
Quality Level: 100
reaction suitability: reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group: amine
storage temp.: 2-8°C
ligand:
E7820
Quality Level:
100
reaction suitability:
reactivity: carboxyl reactivereagent type: ligand-linker conjugate
functional group:
amine
storage temp.:
2-8°C
ligand: __
Quality Level: 300
reaction suitability: __
functional group: __
storage temp.: __
ligand:
__
Quality Level:
300
reaction suitability:
__
functional group:
__
storage temp.:
__