Description

• General description: We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product is biobased and thus aligns with "Use of Renewable Feedstocks". Click here for more information.
• Application: Succinic acid has been used:in succinate dehydrogenase mitochondrial assay.[1]as an internal standard in mass spectroscopy.[2]as succinate dehydrogenase substrate in oxygraph analysis to measure respiration rates.[3]
• Biochem/physiol Actions: Succinic acid is a byproduct of anaerobic fermentation in microbes. It is a dicarboxylic acid and an intermediate in Kreb′s cycle.[4] Polymorphism in succinate dehydrogenase leads to succinate accumulation. High levels of succinate impairs 2-oxoglutarate epigenetic signalling.[5] Succinate levels may modulate tumor progression.[6] Succinate inhibits histone demethylation and may contribute to epigenetic changes.[7] Succinate is crucial for interleukin-1 β (IL-1β) synthesis during inflammation and immune signalling.[8]
• Other Notes: Succinic Acid: A New Platform Chemical for Biobased Polymers from Renewable Resources