Tocris Bioscience™ Kaempferol

Description

• Activates the mitochondrial Ca2+ uniporter (EC50 = 7 μM)
• Induces caspase-9-mediated apoptosis in cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression
• Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro
• Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells
• Activates transcriptional coactivator with PDZ-binding motif (TAZ) and increases osteoblast differentiation of mesenchymal stem cells while inhibiting adipocyte differentiation
• Naturally occurring flavonoid found in Gingko biloba and red wine
• Kaempferol has antiviral activity against Japanese encephalitis virus (JEV) in infected BHK21 (EC50 = 21.5 μM)
• Kaempferol directly inhibits viral replication and protein expression by binding JEV frameshift site RNA (fsRNA)
• Kaempferol influences frameshift efficiency in virus-infected cells through interfering with a downstream RNA pseudoknot structure
• Kaempferol has also been reported to exhibit activity against herpes simplex virus, influenza viruses (H1N1 and H9N2) and hepatitis B virus under in vitro conditions.