Tocris Bioscience™ DL-AP5 Sodium salt

Description

• DL-AP5 Sodium salt is the sodium salt of DL-AP5 (Cat
• No
• 0105) and a racemic mixture of the D- and L-isomers of AP5, a selective NMDA receptor antagonist that competes with glutamate binding and is commonly used to inhibit NMDA-dependent synaptic plasticity
• D-AP5 (Cat
• No
• 0106) is the more active isomer and displays approximately 52-fold higher potency than the L-isomer, L-AP5 (Cat
• No
• 0107)
• In vitro D-AP5 reduces NMDA-induced depolarization of cortical neurons, with no effect on the response to L-Quisqualic acid (Cat
• No
• 0188) or Kainic acid (Cat
• No
• 0222)
• Following spinal injection of D-AP5, NMDA-response is rapidly reduced, with no effect seen on spontaneously active neurons
• DL mixture, D-isomer and L-isomer also available.