5545830
Tocris Bioscience™ INCA-6
Inhibitor of calcineurin-substrate association
Manufacturer: Fischer Scientific
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Product Type
INCA-6
Molecular Weight (g/mol)
284.31
Inhibitors
INCA-6
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Description
- Inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (Kd = 0.8 mM)
- Inhibits NFAT dephosphorylation and nuclear import
- Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.
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