5545952

Tocris Bioscience™ Paroxetine maleate

Highly potent and selective 5-HT uptake inhibitor

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Purity

>99%

Product Type

Paroxetine maleate

Molecular Weight (g/mol)

445.44

Inhibitors

Paroxetine maleate

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Description

  • Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM)
  • Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively
  • Displays minimal affinity for α1-, α2- or β-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM)
  • Antidepressant and anxiolytic in vivo .

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