5546098
Tocris Bioscience™ VO-OHpic
Potent PTEN inhibitor
Manufacturer: Fischer Scientific
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Purity
>98%
Product Type
VO-OHpic
Molecular Weight (g/mol)
361.16
Inhibitors
VO-OHpic
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Description
- Potent inhibitor of PTEN (phosphatase and tensin homolog) (IC50 = 35 nM)
- Displays selectivity for PTEN over cysteine-based phosphatases such as SopB, MTM, PTPβ and SAC (IC50 values are 588 nM, 4.03, 57.5 and >10 μM respectively)
- Increases PIP2 and PIP3 levels; also increases Akt translocation in NIH/3T3 fibroblasts
- Blocks the immunosuppressant activity of IDO-activated Tregs
- Promotes antitumor inflammatory response in combination with immunotherapy and enhances anticancer chemotherapy in tumor-bearing mice.
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Purity: >98%
Product Type: VO-OHpic
Molecular Weight (g/mol): 361.16
Inhibitors: VO-OHpic
Purity:
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