5546108
Tocris Bioscience™ Wnt-C59
Highly potent PORCN inhibitor
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Purity
>99%
Product Type
Wnt-C59
Molecular Weight (g/mol)
379.45
Inhibitors
Wnt-C59
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Description
- Wnt-C59 is a highly potent inhibitor of MBOAT (membrane-bound O-acyltranferase) family member Porcupine (PORCN) (IC50 = 74 pM) that mediates WNT palmitoylation and secretion
- Wnt-C59 potently inhibits the processing of both canonical (1, 2, 3a, 6, 7b, 8a, 9a, 9b, 10) and non-canonical (4, 5a, 11, 16) Wnt subtypes
- Wnt-C59 blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/β-catenin target genes
- Wnt-C59 treated tumors show a decrease in β-catenincatenin, CyclinD1 and c-Myc
- Wnt-C59 induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021 (Cat
- No
- 4423)
- Wnt-C59 efficiently induces neural differentiation of CTIP2+/COUP-TF1- cells from PSCs in culture
- When grafted into the cortex of adult mice, develop abundant axonal fiber extension toward the spinal cord
- Cell permeable and orally bioavailable.
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