BDB556465

BD Ac-DEVD-CHO Inhibitor

Manufacturer: BD

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For Use With (Application)

Functional assay

Content And Storage

-20°C

Molecular Weight (g/mol)

502.5

Form

Purified

Storage Buffer

Lyophilized powder

Quantity

1 mg

Inhibitors

Ac-DEVD-CHO

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Description

  • Members of ICE/CED-3 cysteine protease family have key roles in inflammation and mammalian apoptosis
  • The ICE family member Caspase-3 (also known as CPP32, Yama, apopain) is activated early in apoptosis and appears to be involved in proteolysis of several important molecules, including poly (ADP ribose) polymerase (PARP) Synthetic tetrapeptide inhibitor for Caspase-3 Used in protease assays Cleaves PARP from 116kD to 85kD residual fragment Cleavage site in PARP is C-terminal to Asp-216 Upstream sequence of cleavage site, DEVD (Asp-Glu-Val-Asp), is utilized as basis for highly specific Caspase-3 substrate, Ac-DEVD-AMC and Caspase-3 inhibitor,Ac-DEVD-CHO Storage Buffer: Lyophilized powder Format: Purified Functional assay

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For Use With (Application):
Functional assay

Content And Storage:
-20°C

Molecular Weight (g/mol):
502.5

Form:
Purified

Storage Buffer:
Lyophilized powder

Quantity:
1 mg

Inhibitors:
Ac-DEVD-CHO

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For Use With (Application):
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Store undiluted at 4°C

Molecular Weight (g/mol):
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Storage Buffer:
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Quantity:
0.1 mg

Inhibitors:
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Store undiluted at 4°C

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For Use With (Application):
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Content And Storage:
-80°C

Molecular Weight (g/mol):
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Form:
Liquid

Storage Buffer:
50mM Tris (pH 8.0) with 100mM NaCl and 50mM Imidazole

Quantity:
10 μg

Inhibitors:
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