MP Biomedicals™ Q-VD-OPH, MP Biomedicals™

Description

• The Q-VD-OPH irreversibily binds to activated Caspases to block apoptosis
• Apoptosis is a physiological form of cell death, which plays an important role in embryogenesis, cellular homoestasis, tissue atrophy, and removal of damaged and mutated cells
• Caspases, which act as molecular chainsaw, are the central components of apoptosis response
• Caspases are Cysteine proteases that cleave after aspartate residue in their substrates
• At least 7 of 14 known mammalian caspases have important role in apoptosis
• Exceptional alternative to the Fluoromethylketone family of inhibitors (these compounds form the basis for important new drug candidates for a wide variety of disease targets) Nontoxic—preliminary study showed no evidence of toxicity in mice injected intraperitoneally with more than 1000mg/kg Improved potency—IC50 values against purified caspases are in the nanomolar range; in an in vitro cell based assay, greater than 90% inhibition of apoptosis was achieved) Optimal dilutions should be determined by the laboratory for each specific application