A Cell-Permeant Pan Caspase Inhibitor of Apoptosis Irreversibly binds to catalytic site of caspase proteases Provided in DMSO for convenient addition to cell culture or extracts Note: Z-VAD-FMK is provided at 20mM in DMSO for convenient addition to cell culture or extracts
The peptide is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability
The suggested concentration for use in the anti-Fas mAb-treated Jurkat cell culture model system is 20μM.