5546123

Tocris Bioscience™ 3PO

PFKFB3 inhibitor

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Purity

>99%

Product Type

3PO

Molecular Weight (g/mol)

210.23

Inhibitors

3PO

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Description

  • Originally reported to inhibit PFKFB3 (IC50 = 25 μM)
  • More recent reports failed to demonstrate activity in a PFKFB3 kinase assay
  • Reduces glycolytic flux and suppresses glucose uptake
  • Inhibits endothelial cell proliferation and causes G2/M cell cycle arrest in vitro
  • Attenuates vessel sprouting and tumor growth in vivo
  • Amplifies the antiangiogenic effect of VEGFR blockade.

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