5546184

Tocris Bioscience™ Rhosin hydrochloride

Rho GTPase inhibitor

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Purity

>98%

Product Type

Rhosin hydrochloride

Molecular Weight (g/mol)

394.86

Inhibitors

Rho GTPase Inhibitors

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Description

  • Rho GTPase inhibitor (Kd = 354 nM)
  • Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF
  • Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs
  • Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro
  • Also induces neurite outgrowth in synergy with NGF.

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