7114671
Tocris Bioscience™ Pomalidomide
Cereblon binder; also TNF-α inhibitor and antiangiogenic
Manufacturer: Fischer Scientific
CAS Number: 19171-19-8
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Chemical Name or Material
4-Amino-2-(2,6-dioxo-3-piperidinyl)-1 H-isoindole-1,3(2 H)-dione
Assay Percent Range
>98%
Molecular Formula
C13H11N3O4
Purity
98%
CAS
19171-19-8
Target
Ubiquitin Ligase (E3) Inhibitors
Formula Weight
Observed MW: 273.24
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Description
- Potent TNF-α inhibitor (IC50 = 13 nM)
- Also potently inhibits IL-2 (EC50 = 8 nM)
- Thalidomide derivative
- Binds cereblon and inhibits its ubiquitination
- Exhibits antiproliferative effects in a Namalwa lymphoma cell line
- Antiangiogenic
- Promotes degradation of transcription factor SALL4.
SAFETY INFORMATION
- Recommended Storage : Store at 4°C
Compare Similar Items
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Chemical Name or Material: 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1 H-isoindole-1,3(2 H)-dione
Assay Percent Range: >98%
Molecular Formula: C13H11N3O4
Purity: 98%
CAS: 19171-19-8
Target: Ubiquitin Ligase (E3) Inhibitors
Formula Weight: Observed MW: 273.24
Chemical Name or Material:
4-Amino-2-(2,6-dioxo-3-piperidinyl)-1 H-isoindole-1,3(2 H)-dione
Assay Percent Range:
>98%
Molecular Formula:
C13H11N3O4
Purity:
98%
CAS:
19171-19-8
Target:
Ubiquitin Ligase (E3) Inhibitors
Formula Weight:
Observed MW: 273.24
Chemical Name or Material: 6-[[(2 S)-3-Cyclopentyl-1-oxo-2-[4-(trifluoromethyl)-1 H-imidazol-1-yl]propyl]amino]-3-pyridinecarboxylic acid
Assay Percent Range: >98%
Molecular Formula: C18H19F3N4O3
Purity: 98%
CAS: 1215197-37-7
Target: Glucokinase/GCK
Formula Weight: Observed MW: 396.36
Chemical Name or Material:
6-[[(2 S)-3-Cyclopentyl-1-oxo-2-[4-(trifluoromethyl)-1 H-imidazol-1-yl]propyl]amino]-3-pyridinecarboxylic acid
Assay Percent Range:
>98%
Molecular Formula:
C18H19F3N4O3
Purity:
98%
CAS:
1215197-37-7
Target:
Glucokinase/GCK
Formula Weight:
Observed MW: 396.36
Chemical Name or Material: 6-Fluoro-2-(2′-fluoro[1,1′-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium
Assay Percent Range: >99%
Molecular Formula: C23H14F2NO2Na
Purity: __
CAS: 96201-88-6
Target: DHODH Inhibitors
Formula Weight: Observed MW: 397.35
Chemical Name or Material:
6-Fluoro-2-(2′-fluoro[1,1′-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium
Assay Percent Range:
>99%
Molecular Formula:
C23H14F2NO2Na
Purity:
__
CAS:
96201-88-6
Target:
DHODH Inhibitors
Formula Weight:
Observed MW: 397.35
Chemical Name or Material: (Pyridin-3-yl)methyl 4-(2-aminophenylcarbamoyl)benzylcarbamate
Assay Percent Range: >99%
Molecular Formula: C21H20N4O3
Purity: __
CAS: 209783-80-2
Target: __
Formula Weight: Observed MW: 376.41
Chemical Name or Material:
(Pyridin-3-yl)methyl 4-(2-aminophenylcarbamoyl)benzylcarbamate
Assay Percent Range:
>99%
Molecular Formula:
C21H20N4O3
Purity:
__
CAS:
209783-80-2
Target:
__
Formula Weight:
Observed MW: 376.41