Thermo Scientific™ Coagulase Plasma

Description

• Detect coagulase enzyme in staphylococci with Thermo Scientific™ Remel™ Coagulase Plasma
• The enzyme coagulase acts on a constituent of rabbit plasma to produce a thrombin-like substance which activates fibrinogen to form fibrin clot
• In 1940, Fairbrother and Chapman et al
• reported pathogenic staphylococci can be identified based on the ability to coagulate plasma
• 1,2 Chapman found rabbit plasma to be superior to other types of plasma in terms of clotting activity
• 3 Bayliss and Hall recommended replacing the citrate anticoagulant with EDTA to avoid false-positive clots
• 4 Detect coagulase enzyme in staphylococci with Coagulase Plasma
• The enzyme coagulase acts on a constituent of rabbit plasma (coagulase reacting factor) to produce a thrombin-like substance
• This substance activates fibrinogen to form fibrin which results in the formation of a fibrin clot
• Coagulase is present in two forms: bound coagulase, or clumping factor, remains attached to the cell wall of the organism; free coagulase is an extracellular enzyme produced when the organism is cultured in broth
• Bound coagulase is detected in the slide test, while the tube test will detect bound and free coagulase
• Rapid: Results within 10 seconds
• Accurate results: Presence of EDTA as an anticoagulant helps avoiding false-positive clots Lyophilized Coagulase plasma is rehydrated before use for this test
• Not all products are available for sale in all territories
• Please inquire
• Remel™ and Oxoid™ products are now part of the Thermo Scientific brand.