4785535
SB 431542, Tocris Bioscience™
Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7
Manufacturer: Fischer Scientific
CAS Number: 301836-41-9
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CAS
301836-41-9
Molecular Formula
C22H16N4O3
Formula Weight
384.39
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | SB 431542, Tocris Bioscience™ | Fischer Scientific | ₹ 18,566.52 | |
| | SB 431542, Tocris Bioscience™ | Fischer Scientific | ₹ 39,614.28 | |
 | Medchemexpress LLC HY-10431 50mg , SB-431542 CAS:301836-41-9 Purity:>98% | Medchemexpress LLC | ₹ 32,341.68 | |
| | MilliporeSigma™ Calbiochem™ TGF-β RI Kinase Inhibitor VI, SB431542 | MilliporeSigma™ | ₹ 16,547.30 | |
 | eMolecules SB-431542 | 301836-41-9 | MFCD05865244 | 50mg | eMolecules | ₹ 13,853.88 | |
 | Selleck Chemical LLC SB431542 10mg 301836-41-9 | Selleck Chemical LLC | ₹ 20,226.38 | |
 | Medchemexpress LLC SB-431542 | 301836-41-9 | MFCD05865244 | 10mg | Medchemexpress LLC | ₹ 8,624.45 | |
 | Sigma Aldrich Fine Chemicals Biosciences SB 431542 hydrate | 301836-41-9 | MFCD11045982 | 5 mg | Sigma Aldrich Fine Chemicals Biosciences | ₹ 20,123.71 | |
 | Apexbio Technology LLC SB 431542, 301836-41-9, MFCD05865244, 10 mg | Apexbio Technology LLC | ₹ 6,588.12 | |
 | Selleck Chemical LLC SB431542 50mg 301836-41-9 | Selleck Chemical LLC | ₹ 76,422.19 |
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Description
- Description SB 431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor/ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7
- Suppresses TGF-β-induced proliferation of human osteosarcoma cells
- Replaces SOX2 in reprogramming of fibroblasts into iPSCs
- Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells
- Inhibits TGF-β-induced EMT, migration, invasion and VEGF secretion in several human cancer cell lines
- SB 431542 synthesized to cGMP guidelines also available
- For more information about how SB 431542 may be used, see our protocols: 3D Culture of Lung Alveolar Cells, Differentiation of Hematopoietic Progenitors from hPSCs, Generating Midbrain Dopaminergic Neurons from hPSCs, Generating Vascular Organoids, Accelerated Induction of Cortical Neurons from hiPSCs .
SAFETY INFORMATION
- Recommended Storage : Store at Room Temperature
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CAS: 301836-41-9
Molecular Formula: C22H16N4O3
Formula Weight: 384.39
CAS:
301836-41-9
Molecular Formula:
C22H16N4O3
Formula Weight:
384.39
CAS: 1173022-21-3
Molecular Formula: C19H10N2O3.C2H4O2
Formula Weight: Observed MW: 374.35
CAS:
1173022-21-3
Molecular Formula:
C19H10N2O3.C2H4O2
Formula Weight:
Observed MW: 374.35
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