Description

• IA-Alkyne is a broad spectrum cysteine reactive probe
• Covalently binds cysteine residues in proteins
• Can be utilized for covalent fragment-based ligand discovery (FBLD) and to identify Zn2+-binding cysteines
• Used as a click-chemistry handle to attach a fluorophore or biotin to reactive cysteines in proteins for visualization by in-gel fluorescence or identification by mass spectrometry, respectively
• Covalently binds cysteine residues in and activates TRPA1 channels.