7082192
Tocris Bioscience™ AM 6545
High affinity and selective CB1 antagonist
Manufacturer: Fischer Scientific
CAS Number: 1245626-05-4
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Chemical Name or Material
AM 6545
Synonym
5-[4-(4-Cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide
Molecular Formula
C26H23Cl2N5O3S
Physical Form
Solid
Purity
>98%
CAS
1245626-05-4
Solubility
Soluble to 20mM in DMSO
Formula Weight
556.46
Product Type
Bioactive Small Molecule
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ AM 6545 | -- | ₹ 30,972.00 | ||
Tocris Bioscience™ AM 6545 | -- | ₹ 1,29,495.00 | ||
AM6545 | -- | ₹ 9,167.00 | ||
1245626-05-4 | AM6545 | -- | ₹ 3,560.00 - ₹ 1,02,528.00 |
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Description
- High affinity and selective CB1 antagonist (Ki = 3.3 nM)
- Exhibits >100-fold selectivity for CB1 over CB2 receptors
- Improves glucose homeostasis, reverses hepatic steatosis and reduces body weight in diet-induced obese mice
- Orally available and non-brain penetrant.
SAFETY INFORMATION
- Recommended Storage : Store at 4°C