7110774
Tocris Bioscience™ EPPTB
Trace amine 1 (TA1) receptor antagonist/inverse agonist
Manufacturer: Fischer Scientific
CAS Number: 1110781-88-8
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Chemical Name or Material
N-(3-Ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)benzamide
Target
Trace Amine 1 (TA1) Receptor Antagonists
Formula Weight
378.39
CAS
1110781-88-8
Molecular Formula
C20H21F3N2O2
Purity
>99%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ EPPTB | -- | ₹ 92,916.00 | ||
Tocris Bioscience™ EPPTB | -- | ₹ 22,517.00 | ||
Sigma Aldrich Fine Chemicals Biosciences EPPTB >=95% (HPLC) | 1110781-88-8 | MFCD21605509 | 5MG | -- | ₹ 11,230.02 | ||
eMolecules Medchem Express / Ro 5212773 / 5mg / 680109508 / HY-110098 / / 1110781-88-8 / MFCD21605509 / 378.395 / C20H21F3N2O2 | -- | ₹ 11,790.72 | ||
1110781-88-8 | EPPTB | -- | ₹ 4,005.00 - ₹ 2,89,428.00 |
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Description
- Trace amine 1 (TA1) receptor antagonist/inverse agonist; exhibits a higher potency at the mouse TA1 receptor than the rat and human TA1 receptors (IC50 values are 27.5, 4539 and 7487 nM, respectively)
- Blocks the TA1 receptor-mediated activation of an inwardly rectifying K+ current, which increases the firing frequency of dopamine (DA) neurons in the ventral tegmental area
- Increases DA potency at the D2 receptor
- Also displays inverse agonism, reducing basal cAMP levels in vitro (IC50 = 19 nM).
SAFETY INFORMATION
- Recommended Storage : Store at 4°C