7110784
Tocris Bioscience™ Nepicastat hydrochloride
Potent and selective dopamine β-hydroxylase (DBH) inhibitor; orally bioavailable
Manufacturer: Fischer Scientific
CAS Number: 170151-24-3
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Chemical Name or Material
5-(Aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-2H-imidazole-2-thione hydrochloride
Target
Hydroxylase Inhibitors
Formula Weight
331.81
CAS
170151-24-3
Molecular Formula
C14H15F2N3S.HCl
Purity
>98%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ Nepicastat hydrochloride | -- | ₹ 20,559.00 | ||
Tocris Bioscience™ Nepicastat hydrochloride | -- | ₹ 85,929.50 | ||
Apexbio Technology LLC Nepicastat (SYN-117) HCl,5mg CAS# 170151-24-3 | -- | ₹ 5,963.00 | ||
eMolecules Medchem Express / Nepicastat (hydrochloride) / 5mg / 446262678 / HY-13289A / / 170151-24-3 / MFCD00954638 / 331.810 / C14H16ClF2N3S | -- | ₹ 8,646.35 | ||
Sigma Aldrich Fine Chemicals Biosciences Nepicastat hydrochloride >=95% (HPLC) | 170151-24-3 | MFCD00954638 | 5MG | -- | ₹ 12,864.95 | ||
Sigma Aldrich Fine Chemicals Biosciences Nepicastat hydrochloride >=95% (HPLC) | 170151-24-3 | MFCD00954638 | 25MG | -- | ₹ 50,730.00 | ||
170151-24-3 | (S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1h-imidazole-2(3h)-thione hydrochloride | -- | ₹ 2,670.00 - ₹ 31,773.00 |
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Description
- Potent and selective dopamine β-hydroxylase (DBH) inhibitor (IC50 = 9 nM)
- Selective for DBH over 12 other enzymes
- Decreases noradrenaline and increases dopamine levels in tissues and plasma in hypertensive rats
- Prevents progressive left ventricular dysfunction in an in vivo heart failure model
- Also potentiates the stimulus effects of cocaine without producing cocaine-like effects in rats
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C