7110801
Tocris Bioscience™ ZLN 024 hydrochloride
Allosteric AMPK activator
Manufacturer: Fischer Scientific
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Chemical Name or Material
2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]pyrimidine hydrochloride
Molecular Formula
C13H13BrN2OS.HCl
Purity
>99%
Target
AMPK Activators
Formula Weight
361.69
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Description
- ZLN 024 hydrochloride is an allosteric AMP-activated protein kinase (AMPK) activator; allosterically stimulates active AMPK heterotrimers, increasing the activity of α1β1γ1 by 1.5-fold and α2β1γ1 by 1.7-fold (EC50 values are 0.42 and 0.95 μM, respectively)
- Inhibits dephosphorylation of AMPK Thr-172 by PP2Cα
- Stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio
- Also decreases fatty acid synthesis and glucose output in primary hepatocytes
- Improves glucose tolerance and decreases cholesterol content in db/db mice.
SAFETY INFORMATION
- Recommended Storage : Store at 4°C
Compare Similar Items
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Chemical Name or Material: 2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]pyrimidine hydrochloride
Molecular Formula: C13H13BrN2OS.HCl
Purity: >99%
Target: AMPK Activators
Formula Weight: 361.69
Chemical Name or Material:
2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]pyrimidine hydrochloride
Molecular Formula:
C13H13BrN2OS.HCl
Purity:
>99%
Target:
AMPK Activators
Formula Weight:
361.69
Chemical Name or Material: N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-benzamide
Molecular Formula: C31H31ClFN7O2
Purity: >99%
Target: Aurora Kinase Inhibitors
Formula Weight: 588.07
Chemical Name or Material:
N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-benzamide
Molecular Formula:
C31H31ClFN7O2
Purity:
>99%
Target:
Aurora Kinase Inhibitors
Formula Weight:
588.07
Chemical Name or Material: 1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene
Molecular Formula: C22H12Cl4N2O4
Purity: >98%
Target: Histone Demethylase Inhibitors
Formula Weight: 510.15
Chemical Name or Material:
1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene
Molecular Formula:
C22H12Cl4N2O4
Purity:
>98%
Target:
Histone Demethylase Inhibitors
Formula Weight:
510.15
Chemical Name or Material: 4-Methyl-5-(2-pyrazinyl)-3H-1,2-dithiole-3-thione
Molecular Formula: C8H6N2S3
Purity: >99%
Target: Nrf2 Modulators
Formula Weight: 226.34
Chemical Name or Material:
4-Methyl-5-(2-pyrazinyl)-3H-1,2-dithiole-3-thione
Molecular Formula:
C8H6N2S3
Purity:
>99%
Target:
Nrf2 Modulators
Formula Weight:
226.34