7110872

Tocris Bioscience™ GW 501516

Potent and selective PPARδ agonist

Manufacturer: Fischer Scientific

CAS Number: 317318-70-0

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Chemical Name or Material

2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic acid

Target

PPAR delta Receptor Agonists

Formula Weight

453.5

CAS

317318-70-0

Molecular Formula

C21H18F3NO3S2

Purity

>98%

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Description

  • Potent and selective PPARδ agonist (EC50 = 1.2 nM)
  • Displays <1000-fold selectivity over other PPAR subtypes
  • Increases ABC A1 transporter expression and induces apolipoprotein A1-mediated cholesterol efflux in vitro
  • Also increase serum HDL cholesterol and lowers small, dense LDL levels in obesity in vivo models.

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C