7110929
Tocris Bioscience™ Tolcapone
COMT inhibitor; also inhibits transthyretin aggregation
Manufacturer: Fischer Scientific
CAS Number: 134308-13-7
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Chemical Name or Material
(3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
Synonym
Tasmar, Ro 40-7592
Molecular Formula
C14H11NO5
Purity
>99%
CAS
134308-13-7
Target
Catechol O-Methyltransferase (COMT) Inhibitors
Formula Weight
273.24
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Description
- COMT inhibitor
- Inhibits both brain and peripheral COMT
- Also binds transthyretin (TTR) with high affinity (Kd1 and Kd2 values are 21 and 58 nM, respectively)
- Inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro
- Stabilizes TTR in mice and humans in vivo
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at 4°C
Compare Similar Items
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Chemical Name or Material: (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
Synonym: Tasmar, Ro 40-7592
Molecular Formula: C14H11NO5
Purity: >99%
CAS: 134308-13-7
Target: Catechol O-Methyltransferase (COMT) Inhibitors
Formula Weight: 273.24
Chemical Name or Material:
(3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
Synonym:
Tasmar, Ro 40-7592
Molecular Formula:
C14H11NO5
Purity:
>99%
CAS:
134308-13-7
Target:
Catechol O-Methyltransferase (COMT) Inhibitors
Formula Weight:
273.24
Chemical Name or Material: (-)-3-[3-Bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-N,4-dimethylbenzamide
Synonym: __
Molecular Formula: C22H19BrF2N2O3
Purity: >98%
CAS: 1358027-80-1
Target: p38 Inhibitors
Formula Weight: 477.3
Chemical Name or Material:
(-)-3-[3-Bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-N,4-dimethylbenzamide
Synonym:
__
Molecular Formula:
C22H19BrF2N2O3
Purity:
>98%
CAS:
1358027-80-1
Target:
p38 Inhibitors
Formula Weight:
477.3
Chemical Name or Material: 5-[(2-Benzothiazolylthio)methyl]-2,4-dihydro-4-methyl-3H-1,2,4-triazole-3-thione
Synonym: __
Molecular Formula: C11H10N4S3
Purity: >98%
CAS: 315702-40-0
Target: Multidrug Transporter Inhibitors
Formula Weight: 294.42
Chemical Name or Material:
5-[(2-Benzothiazolylthio)methyl]-2,4-dihydro-4-methyl-3H-1,2,4-triazole-3-thione
Synonym:
__
Molecular Formula:
C11H10N4S3
Purity:
>98%
CAS:
315702-40-0
Target:
Multidrug Transporter Inhibitors
Formula Weight:
294.42
Chemical Name or Material: 2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide
Synonym: __
Molecular Formula: C16H10ClF6NO2
Purity: >98%
CAS: 303126-97-8
Target: Nuclear Receptor Agonists
Formula Weight: 397.7
Chemical Name or Material:
2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide
Synonym:
__
Molecular Formula:
C16H10ClF6NO2
Purity:
>98%
CAS:
303126-97-8
Target:
Nuclear Receptor Agonists
Formula Weight:
397.7