7166782
Tocris™ A 317491 sodium salt
Selective, high affinity P2X3 and P2X2/3 antagonist; antinociceptive
Manufacturer: Fischer Scientific
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Chemical Name or Material
5-[[[(3-Phenoxyphenyl)methyl][(1 S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-1,2,4-benzenetricarboxylic acid disodium salt
Molecular Formula
C33H25NO8Na2
Product Type
Antagonist
Target
P2X Receptor Antagonists
Formula Weight
609.54
Purity
98%
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Description
- Selective, high affinity non-nucleotide P2X3 and P2X2/3 receptor antagonist (Ki values are 9, 22, 22 and 92 nM at human P2X2/3, rat P2X3, human P2X3 and rat P2X2/3, respectively); blocks recombinant human and rat P2X3 and P2X2/3 receptor-mediated calcium flux (Ki = 22 - 92 nM)
- Exhibits selectivity over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes (IC50 > 5 μM)
- Reduces mechanical allodynia and thermal hyperalgesia in the CCI in vivo models
- Antinociceptive.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
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Chemical Name or Material: 5-[[[(3-Phenoxyphenyl)methyl][(1 S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-1,2,4-benzenetricarboxylic acid disodium salt
Molecular Formula: C33H25NO8Na2
Product Type: Antagonist
Target: P2X Receptor Antagonists
Formula Weight: 609.54
Purity: 98%
Chemical Name or Material:
5-[[[(3-Phenoxyphenyl)methyl][(1 S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-1,2,4-benzenetricarboxylic acid disodium salt
Molecular Formula:
C33H25NO8Na2
Product Type:
Antagonist
Target:
P2X Receptor Antagonists
Formula Weight:
609.54
Purity:
98%
Chemical Name or Material: __
Molecular Formula: C18H16FN3O
Product Type: Inhibitor
Target: __
Formula Weight: 309.34
Purity: 98%
Chemical Name or Material:
__
Molecular Formula:
C18H16FN3O
Product Type:
Inhibitor
Target:
__
Formula Weight:
309.34
Purity:
98%
Chemical Name or Material: __
Molecular Formula: C22H21ClN4O4
Product Type: Agonist
Target: __
Formula Weight: 440.88
Purity: 98%
Chemical Name or Material:
__
Molecular Formula:
C22H21ClN4O4
Product Type:
Agonist
Target:
__
Formula Weight:
440.88
Purity:
98%
Chemical Name or Material: __
Molecular Formula: C16H17ClN2O4S
Product Type: Inhibitor
Target: __
Formula Weight: 368.84
Purity: 98%
Chemical Name or Material:
__
Molecular Formula:
C16H17ClN2O4S
Product Type:
Inhibitor
Target:
__
Formula Weight:
368.84
Purity:
98%