78-202

Tocris Bioscience™ CU-76

Manufacturer: Tocris Bioscience™

CAS Number: 2400954-58-5

Select a Size

Pack Size SKU Availability Price
Each of 1 78-202-Each-of-1 In Stock ₹ 16,384.74

78-202 - Each of 1

₹ 16,384.74

In Stock

Quantity

1

Base Price: ₹ 16,384.74

GST (18%): ₹ 2,949.253

Total Price: ₹ 19,333.993

Chemical Name or Material

Methyl 4-amino-6-[(3,5-difluoro-4-iodophenyl)amino]-1,3,5-triazine-2-carboxylate

Quantity

2 mg

Molecular Formula

C11H8F2IN5O2

CAS

2400954-58-5

Target

STING/TMEM173

Purity

0.98

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Description

  • CU-76 is a selective cyclic GMP-AMP synthase (cGAS) inhibitor (IC50 = 0.24 μM)
  • It specifically inhibits cGAS-STING pathway and has no effect on other nucleic acid sensing pathways such as the RIG-I-MAVS or Toll-like receptor pathways
  • CU-76 reduces DNA-induced IFN regulatory factor 3 (IRF3) dimerization in a dose-dependent manner, and it decreases production of IFN-β in THP-1 cells stimulated with interferon-stimulatory DNA.

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C

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Show Difference

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Tocris Bioscience™

78-202

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Chemical Name or Material:
Methyl 4-amino-6-[(3,5-difluoro-4-iodophenyl)amino]-1,3,5-triazine-2-carboxylate

Quantity:
2 mg

Molecular Formula:
C11H8F2IN5O2

CAS:
2400954-58-5

Target:
STING/TMEM173

Purity:
0.98

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Fischer Scientific

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__

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Fischer Scientific

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Quantity:
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Fischer Scientific

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Chemical Name or Material:
2-[(Chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide

Quantity:
10 mg

Molecular Formula:
C23H22Cl2N2O3S

CAS:
1035072-16-2

Target:
Glutathione Peroxidase 4/GPX4

Purity:
0.98