11-016-5CBC25

MilliporeSigma™ Calbiochem™O-GlcNAcase Inhibitor, TMG

Manufacturer: MilliporeSigma™

CAS Number: 1009816-48-1

Select a Size

Pack Size SKU Availability Price
Each of 1 11-016-5CBC25-Each-of-1 In Stock ₹ 20,049.27

11-016-5CBC25 - Each of 1

₹ 20,049.27

In Stock

Quantity

1

Base Price: ₹ 20,049.27

GST (18%): ₹ 3,608.869

Total Price: ₹ 23,658.139

Color

Off-white

CAS

1009816-48-1

Formula Weight

248.3g/mol

Content And Storage

Toxicity: Harmful, Store at -20°C, Protect from light, Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Quantity

25 mg

Description

≥98% by HPLC

Molecular Formula

C9H16N2O4S

Solubility

DMSO or H2O

Form

Solid

Other Options

Image Product Name Manufacturer Price Range
50-174-0816
Sigma Aldrich Fine Chemicals Biosciences Thiamet G >=98% (HPLC) | 1009816-48-1 | MFCD15144964 | 25MG
Sigma Aldrich Fine Chemicals Biosciences ₹ 53,286.77
50-1740-817
Sigma Aldrich Fine Chemicals Biosciences Thiamet G | 1009816-48-1 | MFCD15144964 | 5 mg
Sigma Aldrich Fine Chemicals Biosciences ₹ 13,730.67
50-136-4526
Selleck Chemical LLC Thiamet G 25mg 1009816-48-1
Selleck Chemical LLC ₹ 37,988.64
AR00041M
5H-Pyrano[3,2-d]thiazole-6,7-diol, 2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-, (3aR,5R,6S,7R,7aR)-
Aaron Chemicals LLC ₹ 2,053.44 - ₹ 75,207.24
AA04142
1009816-48-1 | Thiamet g
A2B Chem ₹ 3,080.16 - ₹ 1,33,986.96

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Description

  • A cell-permeable, blood-brain barrier-permeant, orally active aminothiazoline that effectively increases O -GlcNAc level of cellular proteins both in cultures (EC 50 = 30 nM, EC max = 200nM in PC3) in vitro and in rats (50mg/kg i.v.; 200mg/kg via drinking water ad libitum ) and mice (500mg/kg via drinking water ad libitum ) in vivo by inhibiting O-GlcNAcase/OGA-mediated O -GlcNAc cleavage in a substrate-competitive ( K i = 21nM), time- and dose-dependent, and highly selective manner
  • TMG long-term treatment in murine AD model effectively prevents loss of motor neurons and reduces NFTs in brain without apparent effect on Tau hyperphosphorylation
  • O -GlcNAcylation is also reported to slow down heat-induced sTAB1 (TAK1-binding protein) aggregation and modulate CK2α kinase activity and substrate selectivity in vitro .

Compare Similar Items

Show Difference

Img

MilliporeSigma™

11-016-5CBC25

--


Color:
Off-white

CAS:
1009816-48-1

Formula Weight:
248.3g/mol

Content And Storage:
Toxicity: Harmful, Store at -20°C, Protect from light, Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Quantity:
25 mg

Description:
≥98% by HPLC

Molecular Formula:
C9H16N2O4S

Solubility:
DMSO or H2O

Form:
Solid

Img

MilliporeSigma™

11-017-51MG

--


Color:
White

CAS:
28575-34-0

Formula Weight:
643.8g/mol

Content And Storage:
Toxicity: Standard Handling, Store at -20°C, Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Quantity:
1 mg

Description:
97% by HPLC

Molecular Formula:
C31H57N5O9

Solubility:
50% acetic acid

Form:
Solid

Img

TECHREF™

11-022-101

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TECHREF™

11-022-102

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