MilliporeSigma™ Calbiochem™ Adenosine Receptor Agonist, NECA

Description

• A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (K i = 14 nM, 20 nM, 2.4μM and 6.2nM for A 1 , A 2A , A 2B , A 3 , respectively)
• Increases intracellular cAMP production (EC 50 = 3.1μM in A 2B expressing CHO cells)
• Shown to increase glucagon release in a dose-dependent manner and inhibit insulin release at low concentrations
• Although at higher concentration some insulin release is observed
• Also, displays a wide range adenosine-dependent effects, such as blocking platelet aggregation and inhibiting DNA synthesis
• When administered at reperfusion, it is shown reduce infarction and block the formation of the mitochondrial permeability transition pore by activating p70S6 kinase.