Cytiva HiTrap™ MabSelect™ SuRe Prepacked Columns

Description

• Prepacked HiTrap columns for process development, screening of purification conditions, and small-scale purification of Mabs
• MabSelect media are suited for the high flowrates and pressures required when scaling up
• Oriented coupling of recombinant Protein A ligand to the agarose matrix via an engineered C-terminal cysteine increases IgG binding capacity over other protein A media High capacity, low ligand leakage, and high-flow base matrix allow purification of Mabs at process scale Fewer regulatory concerns due to the total absence of mammalian culture in the ligand production and purification Designed for use with a syringe, a peristaltic pump, or a chromatography system MabSelect Allows at least five times higher flowrates than conventional cross-linked agarose of similar porosity Recombinant Protein A ligand promotes specificity of binding to F c region of IgG; permits one-step purification MabSelect Xtra™ Same recombinant protein A ligand as MabSelect, but with a smaller particle size and greater porosity, for increased dynamic binding capacity Allows binding from samples with high expression levels of the monoclonal antibody Lowers overall production cost due to the possibility of processing concentrated feedstocks in fewer batches MabSelect SuRe™ (Superior Resistance) Akali-tolerant protein A-derived ligand allows the use of up to 0.5M NaOH for cleaning-in-place (CIP) Permits significant cost savings and extension of cycles in regular production