Description

• A cell-permeable, orally active NSAID (nonsteroidal antiinflammatory drug) that blocks cellular Cox pathway PGE2 (prostaglandin E 2 ) production by inhibiting COX-1 and mPGES-1 (microsomal PGE 2 synthase-1), but not COX-2, activity (IC 50 = 8, 2, and 58μM, respectively), as well as suppresses cellular 5-LO (5-Lypoxygenase; Cat
• No
• 437996) pathway activation by inhibiting FLAP (5-LO-activating protein), rather than 5-LO, activity (<10% by 1μM MK-886)
• Unlike NSAIDs (nonsteroidal antiinflammatory drugs) that target only COX pathway, MK-886 does not cause gastrointestinal damages when applied in vivo .