MilliporeSigma™ Calbiochem™ HIF Inhibitor V

Description

• A cell-permeable phenoxyacrylamido compound that inhibits hypoxia-induced cellular HIF-1α accumulation in a manner similar to LW6 (Cat
• No
• 400083) by upregulating Hippel-Lindau tumor suppressor gene product pVHL, but with much higher potency (IC 50 = 120nM vs 2.44μM, respectively, against hypoxia-induced HRE reporter activity in HCT116 cells)
• Shown to suppress HIF-1 target genes expression in HCT116 cultures and inhibit HUVEC tubule formation (effective conc
• ≥2μM) under hypoxia conditions
• Please note that the molecular weight for this compound is batch-specific due to variable water content
• Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight
• The molecular weight provided represents the baseline molecular weight without water.