50-051-90001
MilliporeSigma™ Calbiochem™ SKP2 E3 Ligase Inhibitor I, C1
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-051-90001-Each-of-1 | In Stock | ₹ 23,479.38 |
50-051-90001 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 23,479.38
GST (18%): ₹ 4,226.288
Total Price: ₹ 27,705.668
Color
Orange Brown
Target Proteins
disrupts p27-Skp2 interaction
Formula Weight
465.3g/mol
Content And Storage
Protect from light
Quantity
25 mg
Description
99% by HPLC
Molecular Formula
C18H13BrN2O4S2
Solubility
DMSO
Form
Powder
Related Products
Description
- A cell-permeable rhodanine compound that upregulates cellular p21 Cip1/Waf1 and p27 Kip1 protein levels (10μM for 16 h in 501 Mel cultures) by preventing Skp2-Cks1-mediated substrate recruitment without affecting the F-box E3 ubiquitin ligase Skp2 interaction with Cks1 or the SCF (Skp1-cullin1-F-box) complex
- Shown to inhibit the proliferation of human breast cancer MCF-7 and melanoma 501 Mel cells (IC 50 = 8 and 30μM, respectively; 16 h incubation)
- Unlike SMIP004 (Cat
- No
- 500517), C1 does not affect cellular Cyclin E/CDK2 kinase activity or Skp2 level
- Please note that the molecular weight for this compound is batch-specific due to variable water content
- Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight
- The molecular weight provided represents the baseline molecular weight without water.
Compare Similar Items
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Color: Orange Brown
Target Proteins: disrupts p27-Skp2 interaction
Formula Weight: 465.3g/mol
Content And Storage: Protect from light
Quantity: 25 mg
Description: 99% by HPLC
Molecular Formula: C18H13BrN2O4S2
Solubility: DMSO
Form: Powder
Color:
Orange Brown
Target Proteins:
disrupts p27-Skp2 interaction
Formula Weight:
465.3g/mol
Content And Storage:
Protect from light
Quantity:
25 mg
Description:
99% by HPLC
Molecular Formula:
C18H13BrN2O4S2
Solubility:
DMSO
Form:
Powder
Color: Light Brown
Target Proteins: blocks p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction
Formula Weight: __
Content And Storage: Protect from light
Quantity: 25 mg
Description: 98% by HPLC
Molecular Formula: C14H10FNOS
Solubility: DMSO
Form: Powder
Color:
Light Brown
Target Proteins:
blocks p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction
Formula Weight:
__
Content And Storage:
Protect from light
Quantity:
25 mg
Description:
98% by HPLC
Molecular Formula:
C14H10FNOS
Solubility:
DMSO
Form:
Powder
Color: __
Target Proteins: ASIC3
Formula Weight: 4561g/mol
Content And Storage: Protect from light
Quantity: 100 μg
Description: 95% by HPLC
Molecular Formula: C196H280N54O61S6
Solubility: Aqueous buffer
Form: Lyophilized
Color:
__
Target Proteins:
ASIC3
Formula Weight:
4561g/mol
Content And Storage:
Protect from light
Quantity:
100 μg
Description:
95% by HPLC
Molecular Formula:
C196H280N54O61S6
Solubility:
Aqueous buffer
Form:
Lyophilized
Color: __
Target Proteins: Major hubs involved in TLR signaling cascade
Formula Weight: __
Content And Storage: Hygroscopic, Protect from light
Quantity: 1 Each
Description: __
Molecular Formula: __
Solubility: __
Form: Solid
Color:
__
Target Proteins:
Major hubs involved in TLR signaling cascade
Formula Weight:
__
Content And Storage:
Hygroscopic, Protect from light
Quantity:
1 Each
Description:
__
Molecular Formula:
__
Solubility:
__
Form:
Solid