MilliporeSigma™ Calbiochem™ CaCC Blocker IV, Benzbromarone

Description

• A cell-permeable uricosuric agent that, in addition to its known efficacy in gout treatment, acts as a reversible CaCC blocker and is reported to be more potent than NFA (Cat
• No
• 481987) and NPPB (Cat
• No
• 484100) in suppressing 500nM Ionomycin- (Cat
• Nos
• 407950, 407952, and 407953) induced I - influx in TMEM16A-expressing HEK293 cells (IC 50 = 9.97, 140, and 150μM, respectively) as well as in blocking voltage-gated Cl - current in TMEM16B-expressing HEK293 cells, while exhibiting much reduced potency against ENaC (α, β, and γ) or CFTR
• Shown to significantly reduce mucin secretion from NHBE (normal human bronchial epithelial) and suppress human ASM (airway smooth muscle) contraction upon muscarinic receptor stimulation.