50-452-10001

MilliporeSigma™ Calbiochem™ Hhat Inhibitor, RU-SKI 43

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 50-452-10001-Each-of-1 In Stock ₹ 22,416.72

50-452-10001 - Each of 1

₹ 22,416.72

In Stock

Quantity

1

Base Price: ₹ 22,416.72

GST (18%): ₹ 4,035.01

Total Price: ₹ 26,451.73

Color

Off-white

Target Proteins

Hhat

Solubility

DMSO

Form

Semi-solid

Description

98% by HPLC

Molecular Formula

C22H30N2O2S

Content And Storage

Protect from light

Quantity

10 mg

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Description

  • A cell-permeable dihydrothienopyridinyl-ethanone compound that acts as an effective inhibitor against MBOAT family member Hhat/hedgehog acyltransferase-catalyzed ShhN palmitoylation in a palmitoyl CoA-noncompetitive ( K i = 6,9μM; [ShhN] = 38μM) and ShhN-uncompetitive ( K i = 7.4μM; [palmitoyCoA] = 30μM) manner
  • Effectively prevents Shh- & Hhat-transfected COS-1 cells from activating hedgehog signaling in co-cultured C3H10T1/2 cells (∽80% inhibition with10μM inhibitor) by inhibiting COS-1 intracellular ShhN palmitoylation (by 52% and 80%, respectively, with 10 or 20μM drug treatment) without affecting cellular palmitoylation of H-ras & fyn, myristoylation of c-Src & Wnt3a, Shh autoprosessing, or the protein level and localization of Shh & Hhat
  • Exhibits short plasma half-life in mice ( t 1/2 = 17 min; i.v.).

Compare Similar Items

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Img

MilliporeSigma™

50-452-10001

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Color:
Off-white

Target Proteins:
Hhat

Solubility:
DMSO

Form:
Semi-solid

Description:
98% by HPLC

Molecular Formula:
C22H30N2O2S

Content And Storage:
Protect from light

Quantity:
10 mg

Img

Analytical Sales & Services

50-452-134

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Color:
__

Target Proteins:
__

Solubility:
__

Form:
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Description:
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Molecular Formula:
__

Content And Storage:
__

Quantity:
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Img

Analytical Sales & Services

50-452-174

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Color:
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Target Proteins:
__

Solubility:
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Form:
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Description:
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Molecular Formula:
__

Content And Storage:
__

Quantity:
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Img

Analytical Sales & Services

50-452-176

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Color:
__

Target Proteins:
__

Solubility:
__

Form:
__

Description:
__

Molecular Formula:
__

Content And Storage:
__

Quantity:
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