50-466-00001

MilliporeSigma™ Calbiochem™ P2X Antagonist III

Manufacturer: MilliporeSigma™

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Pack Size SKU Availability Price
Each of 1 50-466-00001-Each-of-1 In Stock ₹ 24,897.96

50-466-00001 - Each of 1

₹ 24,897.96

In Stock

Quantity

1

Base Price: ₹ 24,897.96

GST (18%): ₹ 4,481.633

Total Price: ₹ 29,379.593

Color

White

Target Proteins

P2X7

Solubility

DMSO

Form

Powder

Description

98% by HPLC

Molecular Formula

C28H32N4O2S

Content And Storage

Protect from light

Quantity

10 mg

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Description

  • A phenylthio-nicotinamide that acts as a high affinity P2X 7 antagonist (pKi = 8.7 and 7.9, respectively, against 30nM A-804598 for rat and human P2X 7 binding) and potently inhibits P2X 7 -dependent cellular Ca 2+ mobilization (pIC 50 = 8.3, 7.5, and 7.2, respectively, using 1321N1 expressing human, mouse, or rat P2X 7 ; drug added 0.5 h prior to 3 min 0.25mm BzATP stimulation), while exhibiting much reduced or little potency toward a panel of 50 ion channels, transporters, and receptors
  • Although not suitable for oral dosing due to high hepatic extraction ratios, effective delivery and brain P2X 7 occupancy can be achieved via s.c
  • dosing in rats (30mg/kg) in vivo .

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MilliporeSigma™

50-466-00001

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Color:
White

Target Proteins:
P2X7

Solubility:
DMSO

Form:
Powder

Description:
98% by HPLC

Molecular Formula:
C28H32N4O2S

Content And Storage:
Protect from light

Quantity:
10 mg

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Waters Corp

50-466-003

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Target Proteins:
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Solubility:
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Description:
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Waters Corp

50-466-006

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Target Proteins:
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Solubility:
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Waters Corp

50-466-010

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Solubility:
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Description:
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Molecular Formula:
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Content And Storage:
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