MilliporeSigma™ Calbiochem™ PP2A Activating Ligand, ITH12246

Description

• A cell-permeable, relatively non-toxic, 1,8-naphthyridine derived compound that blocks the inhibitory effect of protein phosphatase inhibitors, such as okadaic acid, on protein phosphatase 2A (PP2A)
• Exhibits blood-brain barrier permeability
• Protects neurons against β-amyloid peptides (Ab1-42) toxicity and okadaic acid (Cat
• No
• 459620)-induced tau hyperphosphorylation
• Also protects against rotenone and oligomycin A induced neurotoxicity in SH-SY5Y neuroblastoma cells (at ∽300nM)
• Prevents the development of glutamate-induced neuronal lesions in rat hippocampal slices by up-regulating PP2A (∽ 3.0μM)
• Shown to reverse the scopolamine-induced memory loss in mice (∽10mg/kg i.p) and significantly reduces the infarct volume in an animal model of stroke (∽2.5mg/kg)
• Also acts as an inhibitor of acetylcholinesterase activity in Electrophorus electricus (IC 50 = 60nM) and human erythrocytes (IC 50 = 780nM).