MilliporeSigma™ Calbiochem™ STING Agonist, 2ʹ3ʹ-cGAMP

Description

• A cyclic-dinucleotide (cyclic-GMP-AMP) based compound that binds to the C-terminal domain of adaptor endoplasmic reticulum protein known as STING with high affinity (K d = 4nM) and induces the synthesis of interferon-b (IFN-b) in mammalian cells (EC 50 = 20nM)
• Shown to increase IFN-b production in M2-polarized macrophages associated with non-small cell lung carcinoma and enhances the expression of M1 markers iNOS and IL-12p40, while simultaneously reducing the expression of the M2 markers, Arg-1 and Fizz1
• Exhibits about 300 fold greater affinity for STING than c-DiGMP, 3′,2′-cGAMP, and 3′,3′-cGAMP and about 75 fold greater affinity over 2′,2′-cGAMP
• Please note that the molecular weight for this compound is batch-specific due to variable water content.