7112419
Tocris Bioscience™ VH 298
High-affinity inhibitor of VHL
Manufacturer: Fischer Scientific
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Product Type
Inhibitor
Molecular Formula
C27H33N5O4S
Content And Storage
Store at -20°C
Target Proteins
Ubiquitin Ligase (E3)
Formula Weight
523.65g/mol
For Use With (Application)
Ubiquitin Ligase (E3) Inhibitors
Related Products
Description
- High-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM)
- Blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating hypoxic response
- Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes, with similar transcriptional profile to hypoxia
- Cell permeable
- Negative control cis VH 298 also available.
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Product Type: Inhibitor
Molecular Formula: C27H33N5O4S
Content And Storage: Store at -20°C
Target Proteins: Ubiquitin Ligase (E3)
Formula Weight: 523.65g/mol
For Use With (Application): Ubiquitin Ligase (E3) Inhibitors
Product Type:
Inhibitor
Molecular Formula:
C27H33N5O4S
Content And Storage:
Store at -20°C
Target Proteins:
Ubiquitin Ligase (E3)
Formula Weight:
523.65g/mol
For Use With (Application):
Ubiquitin Ligase (E3) Inhibitors
Product Type: Long-acting Agonist (LABA)
Molecular Formula: C19H24N2O4.C4H6O6
Content And Storage: Store at 4°C
Target Proteins: Adrenergic beta-2
Formula Weight: 494.49g/mol
For Use With (Application): Adrenergic beta-2 Receptor Agonists
Product Type:
Long-acting Agonist (LABA)
Molecular Formula:
C19H24N2O4.C4H6O6
Content And Storage:
Store at 4°C
Target Proteins:
Adrenergic beta-2
Formula Weight:
494.49g/mol
For Use With (Application):
Adrenergic beta-2 Receptor Agonists
Product Type: Inhibitor
Molecular Formula: C22H22F3N.HCl
Content And Storage: Store at -20°C
Target Proteins: Calcium-Sensing Receptor
Formula Weight: 393.87g/mol
For Use With (Application): Calcium-Sensing Receptor Agonists
Product Type:
Inhibitor
Molecular Formula:
C22H22F3N.HCl
Content And Storage:
Store at -20°C
Target Proteins:
Calcium-Sensing Receptor
Formula Weight:
393.87g/mol
For Use With (Application):
Calcium-Sensing Receptor Agonists
Product Type: Agonist
Molecular Formula: C26H27N5O2.HCl
Content And Storage: Store at -20°C
Target Proteins: 5-HT1A
Formula Weight: 477.99g/mol
For Use With (Application): 5-HT1A Receptor Antagonists
Product Type:
Agonist
Molecular Formula:
C26H27N5O2.HCl
Content And Storage:
Store at -20°C
Target Proteins:
5-HT1A
Formula Weight:
477.99g/mol
For Use With (Application):
5-HT1A Receptor Antagonists