7112419

Tocris Bioscience™ VH 298

High-affinity inhibitor of VHL

Manufacturer: Fischer Scientific

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Product Type

Inhibitor

Molecular Formula

C27H33N5O4S

Content And Storage

Store at -20°C

Target Proteins

Ubiquitin Ligase (E3)

Formula Weight

523.65g/mol

For Use With (Application)

Ubiquitin Ligase (E3) Inhibitors

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Description

  • High-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM)
  • Blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating hypoxic response
  • Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes, with similar transcriptional profile to hypoxia
  • Cell permeable
  • Negative control cis VH 298 also available.

Compare Similar Items

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Fischer Scientific

7112419

High-affinity inhibitor of VHL...


Product Type:
Inhibitor

Molecular Formula:
C27H33N5O4S

Content And Storage:
Store at -20°C

Target Proteins:
Ubiquitin Ligase (E3)

Formula Weight:
523.65g/mol

For Use With (Application):
Ubiquitin Ligase (E3) Inhibitors

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Fischer Scientific

7112420

Low molecular weight, organic compo...


Product Type:
Long-acting Agonist (LABA)

Molecular Formula:
C19H24N2O4.C4H6O6

Content And Storage:
Store at 4°C

Target Proteins:
Adrenergic beta-2

Formula Weight:
494.49g/mol

For Use With (Application):
Adrenergic beta-2 Receptor Agonists

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Fischer Scientific

7112423

Low molecular weight, organic compo...


Product Type:
Inhibitor

Molecular Formula:
C22H22F3N.HCl

Content And Storage:
Store at -20°C

Target Proteins:
Calcium-Sensing Receptor

Formula Weight:
393.87g/mol

For Use With (Application):
Calcium-Sensing Receptor Agonists

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Fischer Scientific

7112427

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Product Type:
Agonist

Molecular Formula:
C26H27N5O2.HCl

Content And Storage:
Store at -20°C

Target Proteins:
5-HT1A

Formula Weight:
477.99g/mol

For Use With (Application):
5-HT1A Receptor Antagonists