R&D Systems™ Pan Caspase OPH Inhibitor Q-VD, Non-omethylated

Description

• Members of the caspase gene family (cysteine proteases with aspartate specificity) play significant roles in both inflammation and apoptosis
• The IC50 range for caspases -1, -3, -8, -9, -10, and -12 is 25 - 400 nM Cells that are induced to undergo apoptosis can be cultured in the presence or absence of Q-VD-OPh inhibitor The Caspase Inhibitor binds to the active site of activated proteases Treated cells can then be assayed for evidence of apoptosis inhibition by examining either whole cells or cell lysates using standard apoptosis assays More effective in preventing apoptosis than the widely used pan Caspase Inhibitor, ZVAD-fmk