Goat Anti-Mouse IgG & IgM Antibody, HRP conjugate

Description

• General description: Immunoglobulin G (IgG) is the most abundant immunoglobulin in the human serum. IgM constitutes 5-10% of total serum immunoglobulins. These immunoglobulins comprise four polypeptide chains with two heavy (H) chains and two light (L) chains. These polypeptide chains are inter-linked by disulfide bonds. IgM is a highly conserved antibody in vertebrates. IgM exists as a pentamer. Both IgG and IgM are secreted by B cells.
• Application: Goat Anti-Mouse IgG & IgM Antibody, HRP conjugate has been used in western blotting[1](1:400) and immunofluorescence (1:500)[2]
• Biochem/physiol Actions: IgG facilitates antibody-dependent cell-mediated cytotoxicity (ADCC). It also aids in the activation of the classical pathway of the complement system. IgG neutralizes virus particles and toxins. IgM, an antibody that is expressed early during an immune response, aids in engulfing apoptotic cells. It exhibits polyreactive and autoreactive functionality. IgM induces tissue homeostasis by mediating the clearance of tissue-based molecules. Lower levels of IgM in serum are associated with increased autoimmune response and a higher risk of developing infections.
• Legal Information: CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany