Monoclonal Anti-Digoxin antibody produced in mouse

Description

• General description: Monoclonal Anti-Digoxin (mouse IgG1 isotype) is derived from the hybridoma DI-22 produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with digoxin- keyhole limpet hemocyanin (KLH). Digoxin is obatained from the leaves of the Digitalis lanata, a foxglove plant. The digoxin molecule is made up of a sugar and a cardenolide. It has a molecular weight is 780.95 Da. It is a odorless white crystal, which is soluble in alcohol and freely soluble in pyridine. It is expressed in the duodenum, kidneys, liver and the blood-brain barrier.
• Specificity: Antibody is specific for digoxin and shows a high affinity for digoxigenin.
• Immunogen: Digoxin-KLH.
• Application: Monoclonal Anti-Digoxin antibody produced in mouse has been used in:enzyme-linked immunosorbent assay (ELISA)dot blotflow cytometry fluorescence in situ hybridization (FISH) DNA hybridizationin-situ hybridization (ISH)immunodetection of the probe and chromosome X
• Biochem/physiol Actions: Digoxin is a phytoestrogen that binds estrogen receptors and produces inotropic effects in cardiac muscle. Studies show that digoxin decreases the risk of breast and uterus cancers that are estrogen sensitive.
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