Phospho-Stat3 (pTyr705) and pan-Stat3 ELISA Kit

Description

• General description: Signal transducers and activators of transcription 3 (STAT3) is a transcription factor that belongs to the family of STAT proteins. The protein contains an Src homology 2 (SH2) domain for protein-protein interactions.[1] STAT3 is activated by phosphorylation on tyrosine 705 by c-Jun N-terminal kinases (JNKs), cytokine receptor-associated kinases, nonreceptor tyrosine kinases, and growth factor receptor tyrosine kinases, in response to growth factors and cytokines.[1][2] Phosphorylation of STAT3 is important for dimer formation and gene expression.[1][2] STAT3 mediates the expression of a variety of genes that are involved in cell proliferation and differentiation. It also aids in pro-cancer immunity.[3] The Phospho-Stat3 (pTyr705) and pan-Stat3 ELISA (enzyme-linked immunosorbent assay) is a very rapid, convenient, and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.
• Immunogen: Stat3 (pTyr705) synthetic phosphopeptide, Recombinant Human Stat3
• Application: Phospho-Stat3 (pTyr705) and pan-Stat3 ELISA Kit has been used in enzyme-linked immunosorbent assay (ELISA) for quantitative measurement of phosphorylated signal transducer and activator of transcription3 (p-STAT3) in liver tissues.[4][5]