Description

• General description: Manganese (II) chloride (MnCl2) might play a key role in integrin activation.[1] Manganese is indispensable for brain function and is an essential cofactor for several key enzymes like superoxide dismutase and enzymes involved in neurotransmitter synthesis. Manganese can modulate iron and calcium homeostasis. Manganese is also used in the magnetic resonance imaging to increase contrast while examining neuronal connections and brain cytoarchitecture. High levels of manganese is toxic to central nervous system and causes Parkinson′s like symptoms called as manganism.[2] MnCl2 has been used in reverse transcription reaction mix to enhance the template-switching efficiency.[3]
• Application: Manganese (II) chloride solution has been used:in manganese enhanced magnetic resonance imaging (MEMRI) to study neuronal disease[4] and manganese toxicity[2]in high ionic strength reaction mixture to determine RNA polymerase I and II activity[5]in reverse transcription reaction mix as a source of Mn2+ ions[3]