Prekallikrein Activator

Description

• General description: Prekallikrein activator (PKA), also known as Factor XIIa, activates prekallikrein to kallikrein. Activated kallikrein cleaves kininogens into kinins (e.g., bradykinin) that can result in a loss of blood pressure. PKA is assayed by its ability to activate prekallikrein, which once activated cleaves a synthetic peptide substrate and releases a chromophore that can be measured spectrophotometrically. The amount of PKA is determined by comparison with reference standard material. Prekallikrein Activator USP Reference standard is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia
• Application: Prekallikrein Activator USP Reference standard, is used to prepare standard solutions for prekallikrein activator assay. Further information is available in chapter, 〈165〉 PREKALLIKREIN ACTIVATO, USP43-NF38 – 6583 of United States Pharmacopeia (USP).
• Other Notes: This product is part of the USP Biologics program.