Mouse Hematopoetic Stem Cell SLAM Code Panel, BD

Description

• The TC15-12F12.2 monoclonal antibody specifically binds to mouse CD150, also known as SLAM (signaling lymphocyte activation molecule)
• CD150 is a type 1 transmembrane glycoprotein that is a member of the CD2 subfamily of the Ig superfamily
• It is encoded by the Slamf1 (signaling lymphocytic activation molecule family member 1) gene
• CD150 is differentially expressed on subsets of thymocytes, T and B lymphocytes, dendritic cells, macrophages, and endothelial cells
• SLAM plays multiple roles in innate and adaptive immunity serving as an adhesion molecule and/or coreceptor
• CD150-mediated costimulation of TCR-activated T cells reportedly results in the increased production of IFN-γ by Th1 cells and is required for IL-4 production by T follicular helper cells
• CD150 also plays important roles in hematopoietic cell developmental pathways
• CD150 is differentially expressed by self-renewing adult hematopoietic stem cells (HSC) that are CD150+ whereas non-multipotent hematopoietic progenitor cells are CD150-
• Utilizing additional cell surface markers, lineage-negative CD150+CD48-CD41- cell fractions are reported to be highly enriched for adult HSC
• Host Species: Rat, Hamster, Rat Clone: TC15-12F12.2, HM48-1, MWReg30 Isotype: IgG2a, λ, IgG1, λ 3, IgG1, κ Species Reactivity: Ms Flow Cytometry