Blood Group H Antigen Monoclonal Antibody (89-8), Invitrogen™

Description

• MA1-7674 detects H1 and H2 human blood from human samples
• MA1-7674 has been successfully used in ELISA and agglutination applications
• The MA1-7674 immunogen is a H human blood protein
• For short term storage, store product at 4oC
• For long-term storage, store at -80oC The H antigen is a precursor to the ABO blood group antigens, present in people of all common blood types
• The Bombay phenotype (hh) does not express antigen H on red blood cells, and therefore this type will also lack A or B antigens, similar to the O blood group
• However, unlike O group, the H antigen is absent, hence the individuals produce isoantibodies to antigen H as well as to both A and B antigens
• If they receive blood from someone with O blood group, the anti-H antibodies will bind to the H antigen on the red blood cells of the donor blood and destroy the RBCs by complement-mediated lysis
• Therefore, people with Bombay phenotype can receive blood only from other hh donors, although they can donate as though they were type O
• Some individuals with the blood group A1 may also be able to produce anti-H antibodies due to the complete conversion of all the H antigen to A1 antigen
• Production of the H antigen, or its deficiency in the Bombay phenotype, is controlled at the H locus on chromosome 19
• The H locus contains three exons that span more than 5 kb of genomic DNA, and encodes the fucosyltransferase that produces the H antigen on RBCs
• The H antigen is a carbohydrate sequence with carbohydrates linked mainly to protein (with a minor fraction attached to ceramide moiety).